Stephen Manuck, Ph.D.

  • Distinguished University Professor of Health Psychology and Behavioral Medicine

Graduate Student Advisees:

  • Karissa Miller
  • Patricia Wong

Education & Training

  • PhD, Vanderbilt University

Research Interests

Psychosocial antecedents of cardiovascular disease; genetics of behavior and gene-environment interaction; neurobiology of personality and temperament.

Accepting Graduate Students


Representative Publications

Forbes EE, Ryan ND, Phillips ML, Manuck SB, Worthman CM, Moyles DL, Tarr JA, Sciarrillo SR, Dahl RE. Healthy adolescents' neural response to reward:associations with puberty, positive affect, and depressive symptoms. J Am Acad Child Adolesc Psychiatry. 2010 Feb;49(2):162-72.e1-5.

Manuck, S.B., Flory, J.D., McCaffery, J.M., Matthews, K.A.Mann, J.J., & Muldoon, M.F. (1998) Aggression, impulsivity, and central nervous system serotonergic responsivity in a nonpatient sample. Neuropsychopharmacology 19; 287-299

Jennings, J.R., Muldoon, M.F., Hall, M., Buysse, D.J., & Manuck, S.B. (2007). Self-reported sleep quality is associated with the metabolic syndrome. Sleep, 30(2), 219-223.

Gianaros PJ, Horenstein JA, Hariri AR, Sheu LK, Manuck SB, Matthews KA, & Cohen S. (2008). Potential neural embedding of parental social standing. Social Cognitive & Affective Neuroscience, 3, 91-96.

Gianaros PJ, Matthews KA, Jennings JR, Sheu LK, Manuck SB, & Hariri AR (2008). Individual differences in stressor-evoked blood pressure reactivity vary activation, volume, and functional connectivity of the amygdala. Journal of Neuroscience, 28, 990-999.

Gianaros PJ, Horenstein JA, Cohen S, Matthews KA, Brown SM, Flory JD, Critchley HD, Manuck SB, & Hariri AR (2007). Perigenual anterior cingulate morphology covaries with perceived social standing. Social Cognitive & Affective Neuroscience, 2, 161-173.

Marsland, A.L., Gianaros, P.J., Abramowitch, S.M., Manuck, S.B., & Hariri, A.R. Interleukin-6 covaries inversely with hippocampal grey matter volume in middle-aged adults. Biological Psychiatry 2008 64:484-490.

Manuck, S.B., Phillips, J.E., Gianaros, P.J., Flory, J.D., & Muldoon, M.F. (in press). (2010). Subjective socioeconomic status and presence of the metabolic syndrome in midlife community volunteers. Psychosomatic Medicine.

Halder, I., Marsland, A.L., Cheong, J., Muldoon, M.F., Ferrell, R.E., & Manuck, S.B. (in press). Polymorphisms in the CRP gene moderate an association between depressive symptoms and circulating levels of C-reactive protein. Brain, Behavior and Immunity 2009 Sept 29 [Epub ahead of print]

Marsland, A.L., Prather, A.A.*, Petersen, K.L.*, Cohen, S., & Manuck, S.B. Antagonistic Characteristics are Positively Associated with Inflammatory Markers Independently of Trait Negative Emotionality. Brain, Behavior, and Immunity. 2008 22:753-61.

Marsland, A.L., Petersen, K.L., Sathanoori, R., Flory, J.D., Muldoon, M.F., Neumann, S.A., & Manuck, S.B. Interleukin-6 covaries inversely with cognitive performance among middle-aged community volunteers. Psychosomatic Medicine; 2006 68:895-903

Marsland, A.L., Cohen, S., Rabin, B.S., & Manuck, S.B. Positive affect and antibody response to hepatitis B vaccination. Brain, Behavior and Immunity; 2006 20:261-269.

Manuck, S.B., Marsland, A.L., Flory, J.D., Gorka, A., Ferrell, R.E., & Hariri, A.R. (in press). Salivary testosterone and a trinucleotide (CAG) length polymorphism in the androgen receptor gene predict amygdala reactivity in men. Psychoneuroendocrinology 2009 Jun 1 [Epub ahead of print]

Manuck, S.B., Brown, S.M., Forbes, E.E., & Hariri, A.R. (2007). Temporal stability of individual differences in amygdala reactivity. American Journal of Psychiatry, 164, 1613-1614.

Manuck, S.B., Bleil, M.E., Petersen, K.L., Flory, J.D., Mann, J.J., Ferrell, R.E., & Muldoon, M.F. (2005). The socio-economic status of communities predicts variation in brain serotonergic responsivity. Psychological Medicine, 35, 519-528.

Manuck, S.B., Kaplan, J.R., & Lotrich, F.E. (2006). Brain serotonin and aggressive disposition in humans and nonhuman primates. In R.J. Nelson (Ed.), Biology of aggression (pp. 65-113). New York, Oxford University Press.

Hariri, A.R., Brown, S.M., Williamson, D.E., Flory, J.D., de Wit, H., & Manuck, S.B. (2006). Preference for immediate over delayed rewards is associated with magnitude of ventral striatal activity. Journal of Neuroscience, 26, 13213-13217.

Kaplan, J.R., & Manuck, S.B. (2008). Ovarian dysfunction and the premenopausal origins of coronary heart disease. Menopause, 15, 768-776.

Manuck, S.B., Flory, J.D., Ferrell, R.E., Dent, K.M., Mann, J.J., & Muldoon , M.F. (1999) Aggression and anger-related traits associated with a polymorphism of the tryptophan hydrocylase gene. Biological Psychiatry 45; 603-614.

Kaplan, J.R., & Manuck, S.B. (1999) Status, stress, and atherosclerosis: The role of environment and individual behavior. Annals of the New York Academy of Sciences 896; 145-161.

Hall M, Muldoon MF, Jennings JR, Buysse DJ, Flory JD, Manuck SB. Self-reported Sleep Duration is Associated with the Metabolic Syndrome in Mid-life Adults. Sleep, 31(5):635-643, 2008.

Gianaros, P.J., Manuck, S.B., Sheu, L.K., Kuan, D.C., Votruba-Drzal, E., Craig, A.E., Hariri, A.R. (2011). Parental education predicts corticostriatal functionality in adulthood. Cerebral Cortex, 21, 896-910.

Gianaros, P.J., & Manuck, S.B. (2010) Neurobiological pathways linking socioeconomic position and health. Psychosomatic Medicine, 72, 450-461.

Gianaros, P.J., Hariri, A.R., Sheu, L.K., Muldoon, M.F., Sutton-Tyrrell, K., & Manuck, S.B. (2009). Preclinical atherosclerosis covaries with individual differences in reactivity and functional connectivity of the amygdala. Biological Psychiatry, 65, 943-950.

Kamarck, T.W., Muldoon, M.F., Manuck, S.B., Haskett, R.F., Cheong, J., Flory, J.D. & Vella, E. (2011) Citalopram improves metabolic risk factors among high hostile adults: Results of a placebo-controlled intervention. Psychoneuroendocrinology, 36, 1070-1079.

Kamarck TW, Haskett RF, Muldoon M, Flory JD, Anderson B, Bies R, Pollock B & Manuck SB. Citalopram intervention for hostility: Results of a randomized clinical trial. Journal of Consulting and Clinical Psychology, 77, 174-188, 2009.

Creswell, K.G., Sayette, M.A., Manuck, S.B., Ferrell, R.E., Hill, S.Y.& Dimoff, J.D. (2012). DRD4 Polymorphism Moderates the Effect of Alcohol Consumption on Social Bonding. PLoS ONE, 7(2) e29814, 1-9.

Roecklein, K.A., Wong, P.M., Miller, M.A., Franzen, P.L., Ferrell, B.A., Manuck, S.B. (2012, in press). Melanopsin gene variations interact with season to predict sleep timing and chronotype. Chronobiology International.

Accepting Graduate Students